1Chabahar University of Maritime and Marine Sciences, Chabahar, Iran
2Jondishapour University of Medical Sciences, Ahvaz, Iran
Compounds obtained from marine organisms have been isolated due to their anti-bacterial and antifungal activities. In this study, the antifungal activity of aqueous-methanol, methanol, chloroform and n-hexane extracts of body wall, guts and white strings of sea cucumber (Holothuria leucospilota) collected from Chabahar Bay in 100 to 2000 μg/ml concentrations is discussed. The antifungal test on fungal strains (A. niger, A. flavus, A. fumigatus, A. brasiliensis) and C.albicans yeast was conducted by disk diffusion and broth macro-dilution methods. Growth inhibition zone was not observed in the first method. In the second method, the body wall extract at the concentration of 2000 μg/ml inhibited the growth of all the four fungal strains. Also, white string extracts at concentrations of 1000 to 2000 μg/ml inhibited, to some extent, the growth of A. niger and A. fumigatus and brasiliensis. The best inhibitory effect of this extract in the mentioned concentrations was on A. flavus. The guts extract had no effect.